欧盟重新评估二氧化钛作为食品添加剂的安全性
2021年5月6日,欧盟据欧盟食品安全局(EFSA)消息,重新欧盟食品添加剂和调味剂小组( FAF )重新评估了 二氧化钛(titanium dioxide )(E171)作为食品添加剂的评估品添安全性。 根据现有的氧化所有证据,不能排除该添加剂对遗传毒性的钛作担忧,鉴于存在许多不确定性,为食评估小组得出结论,加剂当E171用作食品添加剂时,全性不再被认为是欧盟安全的。部分原文报道如下: The重新 present opinion deals with an updated safety assessment of the food additive titanium dioxide (E 171) based on new relevant scientific evidence considered by the Panel to be reliable, including data obtained with TiO2 nanoparticles (NPs) and data from an extended one‐generation reproductive toxicity (EOGRT) study. Less than 50% of constituent particles by number in E 171 have a minimum external dimension < 100 nm. In addition, the Panel noted that constituent particles < 30 nm amounted to less than 1% of particles by number. The Panel therefore considered that studies with TiO2 NPs < 30 nm were of limited relevance to the safety assessment of E 171. The Panel concluded that although gastrointestinal absorption of TiO2 particles is low, they may accumulate in the body. Studies on general and organ toxicity did not indicate adverse effects with either E 171 up to a dose of 1,000 mg/kg body weight (bw) per day or with TiO2 NPs (> 30 nm) up to the highest dose tested of 100 mg/kg bw per day. No effects on reproductive and developmental toxicity were observed up to a dose of 1,000 mg E 171/kg bw per day, the highest dose tested in the EOGRT study. However, observations of potential immunotoxicity and inflammation with E 171 and potential neurotoxicity with TiO2 NPs, together with the potential induction of aberrant crypt foci with E 171, may indicate adverse effects. With respect to genotoxicity, the Panel concluded that TiO2 particles have the potential to induce DNA strand breaks and chromosomal damage, but not gene mutations. No clear correlation was observed between the physico‐chemical properties of TiO2 particles and the outcome of either in vitro or in vivo genotoxicity assays. A concern for genotoxicity of TiO2 particles that may be present in E 171 could therefore not be ruled out. Several modes of action for the genotoxicity may operate in parallel and the relative contributions of different molecular mechanisms elicited by TiO2 particles are not known. There was uncertainty as to whether a threshold mode of action could be assumed. In addition, a cut‐off value for TiO2 particle size with respect to genotoxicity could not be identified. No appropriately designed study was available to investigate the potential carcinogenic effects of TiO2 NPs. based on all the evidence available, a concern for genotoxicity could not be ruled out, and given the many uncertainties, the Panel concluded that E 171 can no longer be considered as safe when used as a food additive. 声明:本文所用图片、文字来源《食品伙伴网》,评估品添版权归原作者所有。氧化如涉及作品内容、钛作版权等问题,为食请与本网联系删除。加剂 相关链接:食品添加剂,调味剂,二氧化钛
- 最近发表
- 随机阅读
-
- 含乳饮料中乙酰磺胺酸钾的检测方法优化
- 烈火铸英魂——追记钱铺镇虎栈村党委副书记王靖
- 中铁上海局枞阳项目部为横埠镇黄山村送去防疫物资
- 陈庭华:老渔民新生活
- 一批互联网3.0“黑科技”在京亮相
- 枞阳县全力保障疫情防控期间群众就医需求
- 枞阳八旬老人自建“毛主席革命画像陈列室”
- 大雾袭枞阳 城市如入仙境
- 铁拳行动|吹嘘理科状元曾参加培训 “锦官城文化艺术培训学校”被查
- 枞阳县第四批补充耕地项目通过市级验收
- 我县举行长江流域禁捕禁采联合执法指挥中心授旗出征仪式
- 市人大常委会来枞开展“江淮普法行”之督查行活动
- 果胶对多酚氧化酶活性及热稳定性的影响(一)
- 郑刚调研乡村振兴工作
- 枞阳:瞄准“小切口”靶向纠治民生领域腐败和作风问题
- 我县一宗建设用地成功出让
- 重铬酸钾标准品:确保化学分析实验的准确性和重复性
- 囤房稅2.0一次比較清楚!多屋族、建商怎麼課稅?房價會跌嗎?|天下雜誌
- 十四届县委第一轮巡察(涉粮问题专项巡察)工作动员部署暨业务培训会召开
- “志愿红”闪耀在抗疫一线
- 搜索
-
- 友情链接
-